Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar;12(5):715-26.
doi: 10.2217/fon.15.332. Epub 2015 Dec 11.

Meta-analysis of downregulated E-cadherin as a poor prognostic biomarker for cervical cancer

Jifeng Peng  1 , Shengnan Qi  1 , Ping Wang  1 , Wanyu Li  1 , Lingxie Song  1 , Chunxia Liu  1   2 , Feng Li  1   2
Affiliations
Review

Meta-analysis of downregulated E-cadherin as a poor prognostic biomarker for cervical cancer

Jifeng Peng et al. Future Oncol. 2016 Mar.

Abstract

Aim: This meta-analysis was conducted to evaluate the diagnostic and prognostic functions of E-cadherin expression in cervical cancer.

Methods: PubMed and other databases were searched for articles associated with E-cadherin and cervical cancer. These articles were published before June 2015 and written in English or Chinese. Random-effects model was used to pool odds ratios on the heterogeneity test in the meta-analysis.

Results: All of 20 studies were analyzed, in which 522 (42.6%) subjects exhibited reduced E-cadherin expression. Evaluation of clinicopathologic features showed that the downregulation of E-cadherin was related to the overall survival, clinicopathological parameters and age.

Conclusion: Downregulation of E-cadherin in cervical cancer patients showed poor overall survival. Therefore, E-cadherinmay be a metastasis-suppressor gene in cervical cancer.

Keywords: E-cadherin; biomarker; cervical cancer; meta-analysis; prognosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles