Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb;41(2):119-121.
doi: 10.1016/j.tibs.2015.11.010. Epub 2015 Dec 1.

A Door Opens for Fibrodysplasia Ossificans Progressiva

Takenobu Katagiri  1
Affiliations

A Door Opens for Fibrodysplasia Ossificans Progressiva

Takenobu Katagiri. Trends Biochem Sci. 2016 Feb.

Abstract

Fibrodysplasia ossificans progressiva (FOP), characterized by extra bone formation in soft tissues, is caused by a gain-of-function mutation in ACVR1, a transmembrane receptor. Recently, a potential treatment was developed by identifying a novel molecular mechanism underlying bone formation in FOP. These findings have opened the door to beating FOP.

Keywords: activin; bone morphogenetic protein (BMP); heterotopic ossification; intracellular signaling; ligand; receptor.

PubMed Disclaimer

LinkOut - more resources