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. 2016 Feb;12(2):70-2.
doi: 10.1038/nrneph.2015.199. Epub 2015 Dec 14.

Hypertension in 2015: Resistant hypertension: impact and evolving treatment options

Lilach O Lerman  1 , Stephen C Textor  1
Affiliations

Hypertension in 2015: Resistant hypertension: impact and evolving treatment options

Lilach O Lerman et al. Nat Rev Nephrol. 2016 Feb.

Abstract

Arterial hypertension elevates the risk of adverse renal and cardiovascular outcomes, which can be decreased by maneuvers that lower blood pressure (BP). However, a combination of multiple antihypertensive drugs at optimal doses fails to achieve BP control in up to 15% of the hypertensive population. This has led to a relentless search for novel therapeutic alternatives in order to achieve satisfactory control of BP levels. Several prominent studies published in 2015 have shed light on the risks imposed by uncontrolled or partially treated hypertension, and evaluate new therapeutic modalities designed to address the unmet needs of the treatment-resistant hypertensive individual.

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References

    1. Oparil S, Schmieder RE. New approaches in the treatment of hypertension. Circ Res. 2015;116:1074–95. - PubMed
    1. Sim JJ, Bhandari SK, Shi J, Reynolds K, Calhoun DA, Kalantar-Zadeh K, Jacobsen SJ. Comparative risk of renal, cardiovascular, and mortality outcomes in controlled, uncontrolled resistant, and nonresistant hypertension. Kidney Int. 2015;88:622–32. - PMC - PubMed
    1. Sim JJ, Bhandari SK, Shi J, Liu IL, Calhoun DA, McGlynn EA, Kalantar-Zadeh K, Jacobsen SJ. Characteristics of resistant hypertension in a large, ethnically diverse hypertension population of an integrated health system. Mayo Clin Proc. 2013;88:1099–107. - PMC - PubMed
    1. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373:1275–81. - PubMed
    1. Symplicity HTNI. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903–9. - PubMed

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