Potential protective effect of a G>A SNP in the 3'UTR of HLA-A for Chlamydia trachomatis symptomatology and severity of infection

Abstract

The interindividual differences in response to Chlamydia trachomatis (CT) infections are for an important part based on the differences in our host genetic make-up. In the past, several genes and pathways have been identified and linked to protection against or risk for CT infection (i.e. susceptibility), and/or the severity of infection, with a major emphasis on the development of tubal pathology, one of the main causes of female infertility. In the current study, we analyzed in Dutch Caucasian women whether the carriage of HLA-A G>A SNP (rs1655900) was related to the susceptibility of CT infection in a STD cohort (n = 329) and to the severity of infection in a subfertility cohort (n = 482). We also investigated if this A-allele was linked to increase in severity of symptoms, from mild symptoms (lower genital infection) to lower abdominal pain (upper genital tract infection) to the most severe late complication of tubal pathology, including double-sided tubal pathology. We showed that the carriage of HLA-A SNP rs1655900 studied is not associated with the susceptibility to CT infection based on the data from the STD cohort, but might be protective to the development of late complications (p = 0.0349), especially tubal pathology could be relevant.

Keywords: Chlamydia trachomatis; HLA; SNP; host genetic factors; susceptibility; tubal pathology.

Graphical Abstract Figure.

The A-allele of the HLA-A SNP rs1655900 might protect against late complications of CT infections.

Figure 1.

Carriership of rs1655900 * A in C. trachomatis negative and positive women shows a decreasing trend in C. trachomatis induced complications. CT: C. trachomatis; HSG: hysterosalpingography; AS: asymptomatic; S: symptomatic; LAP: lower Abdominal Pain; TP: tubal pathology; s.s.: single-sided occlusion of the tubae; d.s.: double-sided occlusion of the tubae. Black line: trend based on the severity of Chlamydia infections (dark gray bars).