Reply: Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion

Affiliations

¹ 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 2 Departments of Neurology and Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
² 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK.
³ 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 4 German Center for Neurodegenerative Diseases (DZNE), München, Germany 5 Munich Cluster for Systems Neurology (SyNergy), München, Germany.
⁴ 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 6 Medical Research Council Mitochondrial Biology Unit, Cambridge, UK 7 Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, UK pfc25@medschl.cam.ac.uk.

Comment

Patrick Yu-Wai-Man et al. Brain. 2016 Mar.

. 2016 Mar;139(Pt 3):e18.

doi: 10.1093/brain/awv340. Epub 2015 Dec 10.

¹ 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 2 Departments of Neurology and Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
² 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK.
³ 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 4 German Center for Neurodegenerative Diseases (DZNE), München, Germany 5 Munich Cluster for Systems Neurology (SyNergy), München, Germany.
⁴ 1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK 6 Medical Research Council Mitochondrial Biology Unit, Cambridge, UK 7 Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, UK pfc25@medschl.cam.ac.uk.

No abstract available

Comment on

Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.
Yu-Wai-Man P, Griffiths PG, Chinnery PF. Yu-Wai-Man P, et al. Prog Retin Eye Res. 2011 Mar;30(2):81-114. doi: 10.1016/j.preteyeres.2010.11.002. Epub 2010 Nov 26. Prog Retin Eye Res. 2011. PMID: 21112411 Free PMC article. Review.
Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion.
Carelli V, d'Adamo P, Valentino ML, La Morgia C, Ross-Cisneros FN, Caporali L, Maresca A, Loguercio Polosa P, Barboni P, De Negri A, Sadun F, Karanjia R, Salomao SR, Berezovsky A, Chicani F, Moraes M, Moraes Filho M, Belfort R Jr, Sadun AA. Carelli V, et al. Brain. 2016 Mar;139(Pt 3):e17. doi: 10.1093/brain/awv339. Epub 2015 Dec 10. Brain. 2016. PMID: 26657166 Free PMC article. No abstract available.

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