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Case Reports
. 2016 Apr;61(4):361-2.
doi: 10.1038/jhg.2015.152. Epub 2015 Dec 10.

UV light signature in conjunctival melanoma; not only skin should be protected from solar radiation

Carlo Rivolta  1 , Beryl Royer-Bertrand  1 , Donata Rimoldi  2 , Ann Schalenbourg  3 , Leonidas Zografos  3 , Serge Leyvraz  4 , Alexandre Moulin  3
Affiliations
Case Reports

UV light signature in conjunctival melanoma; not only skin should be protected from solar radiation

Carlo Rivolta et al. J Hum Genet. 2016 Apr.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) A partially pigmented melanoma is seen in the inferior perilimbic area with extension onto the cornea. The isolated inferior and temporal pigmented areas were primary acquired melanosis (patient A). (b) A pigmented melanoma can be observed in the superior perilimbic area (patient B). (c) Mutation spectrum of the two conjunctival melanomas (A: patient A, B: patient B), showing a clear ultraviolet-induced DNA damage signature. No somatic mutations were detected in the melanoma-related genes BRAF and NRAS.
See this image and copyright information in PMC

References

    1. Missotten, G. S., Keijser, S., De Keizer, R. J. & De Wolff-Rouendaal, D. Conjunctival melanoma in the Netherlands: a nationwide study. Invest. Ophthalmol. Vis. Sci. 46, 75–82 (2005). - PubMed
    1. Griewank, K. G., Westekemper, H., Murali, R., Mach, M., Schilling, B., Wiesner, T. et al. Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas. Clin. Cancer Res. 19, 3143–3152 (2013). - PubMed
    1. Yu, G. P., Hu, D. N. & McCormick, S. A. Latitude and incidence of ocular melanoma. Photochem. Photobiol. 82, 1621–1626 (2006). - PubMed
    1. Griewank, K. G., Murali, R., Schilling, B., Scholz, S., Sucker, A., Song, M. et al. TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours. Br. J. Cancer 109, 497–501 (2013). - PMC - PubMed
    1. Ikehata, H. & Ono, T. The mechanisms of UV mutagenesis. J. Radiat. Res. 52, 115–125 (2011). - PubMed

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