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Meta-Analysis
. 2015 Dec 14;10(12):e0144872.
doi: 10.1371/journal.pone.0144872. eCollection 2015.

Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Jie Dong  1 , Yi Chen  2 , Yuchen Tang  3 , Fei Xu  1 , Chaohui Yu  2 , Youming Li  2 , Prasoon Pankaj  4 , Ning Dai  1
Affiliations
Meta-Analysis

Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Jie Dong et al. PLoS One. .

Abstract

Background: Prior work suggested that patients with inflammatory bowel diseases (IBD) have lower body mass index (BMI) than controls and patients with lower BMI have more serious complications.

Goal: The study was aimed to find relationship between BMI in patients with and without IBD, investigate effects of medicine therapy and disease stages on patients' BMI.

Methods: Potentially eligible studies were identified through searching PubMed, Cochrane and Embase databases. Outcome measurements of mean BMI and the number of patients from each study were pooled by a random-effect model. Publication bias test, sensitivity analysis and subgroup analysis were conducted.

Results: A total of 24 studies containing 1442 patients and 2059 controls were included. Main results were as follows: (1) BMI in Crohn's disease (CD) patients was lower than that in health controls (-1.88, 95% CI -2.77 to -1.00, P< 0.001); (2) Medical therapy significantly improved BMI of CD patients (with therapy: -1.58, -3.33 to 0.16; without: -2.09, 95% CI -3.21 to -0.98) while on the contrary not significantly improving BMI of UC patients (with therapy: -0.24, 95% CI -3.68 to 3.20; without: -1.34, 95% CI -2.87 to 0.20, P = 0.57); (3) Both CD and UC patients in active phase showed significantly greater BMI difference compared with controls than those in remission (CD patients: remission: -2.25, 95% CI -3.38 to -1.11; active phase: -4.25, 95% CI -5.58 to -2.92, P = 0.03; UC patients: remission: 0.4, 95% CI -2.05 to 2.84; active phase: -5.38, -6.78 to -3.97, P = 0.001).

Conclusions: BMI is lower in CD patients; medical therapy couldn't improve BMI of IBD patients; the state of disease affects BMI of CD patients and UC patients.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of systematic literature search on BMI and IBD.
Fig 2
Fig 2. Forest plot of the association between BMI and CD.
Fig 3
Fig 3. Forest plot of the association between BMI and UC.
Fig 4
Fig 4. Forest plot of the association between BMI and IBD.
Fig 5
Fig 5. Forest plot of subgroup analysis of BMI in CD patients with or without medicine therapy.
Fig 6
Fig 6. Forest plot of subgroup analysis of BMI in UC patients with or without medicine therapy.
Fig 7
Fig 7. Forest plot of subgroup analysis of BMI in CD patients in active or remission phase.
Fig 8
Fig 8. Forest plot of subgroup analysis of BMI in UC patients in active or remission phase.
See this image and copyright information in PMC

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References

    1. Lankarani KB, Sivandzadeh GR, Hassanpour S. Oral manifestation in inflammatory bowel disease: A review. World journal of gastroenterology: WJG. 2013;19:8571–8579 10.3748/wjg.v19.i46.8571 - DOI - PMC - PubMed
    1. Podolsky DK. Inflammatory bowel disease. The New England journal of medicine. 2002;347:417–429 - PubMed
    1. Ye L, Cao Q, Cheng J. Review of Inflammatory Bowel Disease in China. TheScientificWorldJournal. 2013;296470 10.1155/2013/296470 - DOI - PMC - PubMed
    1. Ye L, Cao Q, Cheng J. Review of Inflammatory Bowel Disease in China. TheScientificWorldJournal. 2013;2013:296470 10.1155/2013/296470 - DOI - PMC - PubMed
    1. Chen Y, Liu L, Wang X, Wang J, Yan Z, Cheng J, et al. Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2013;22(8):1395–408. - PubMed

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