Acetogenins from Annonaceae

Abstract

In recent decades, annonaceous acetogenins have become highly studied plant secondary metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation, mechanism of action, and toxicity. The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics. The compounds are considered biologically in terms of their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities.

Keywords: Acetogenin mimics; Acetogenins; Annonaceae; Anti-cancer activity; Apoptosis; Atypical Parkinsonism; Ionophores; Mitochondria complex I inhibition; Neurotoxicity; Pesticidal activity.