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Review
. 2015 Dec 9;7(317):317ps24.
doi: 10.1126/scitranslmed.aad3106.

Ebola vaccine R&D: Filling the knowledge gaps

Donata Medaglini  1 , Ali M Harandi  2 , Tom H M Ottenhoff  3 , Claire-Anne Siegrist  4 ; VSV-Ebovac Consortium
Collaborators, Affiliations
Review

Ebola vaccine R&D: Filling the knowledge gaps

Donata Medaglini et al. Sci Transl Med. .

Abstract

With an emphasis on systems analyses, the VSV-EBOVAC project harnesses state-of-the-art technologies that illuminate mechanisms behind the observed immunogenicity and reactogenicity of the rVSV-ZEBOV vaccine and ensures that such information is shared among stakeholders.

Trial registration: ClinicalTrials.gov NCT02283099 NCT02287480 NCT02296983.

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Figures

Fig. 1
Fig. 1. Project plan form and functions.
Shown in schematic form is the VSV-EBOVAC structure of the project plan. Blood samples and clinical data are obtained throughout the study, and clinical, immunological, and -omics data are integrated in order to identify molecular signatures associated with the rVSV-ZEBOV vaccine. The project is overseen by a management team consisting of the project coordinator, the scientific coordinator, and the work-package (WP) leaders. (Inset, right) The project is organized and carried out in four WPs. WP1 extends the clinical trials to 12 months and organizes sample distribution between partners.
See this image and copyright information in PMC

References

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