Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar;20(1):9-17.
doi: 10.1007/s10006-015-0538-x. Epub 2015 Dec 11.

Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review

Larissa Fernandes Silva  1 , Cláudia Curra  2 , Marcelo Salles Munerato  3 , Carlos Cesar Deantoni  2 , Mariza Akemi Matsumoto  4 , Camila Lopes Cardoso  1   5 , Marcos Martins Curi  1   5
Affiliations
Review

Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review

Larissa Fernandes Silva et al. Oral Maxillofac Surg. 2016 Mar.

Abstract

Purpose: Surgical management of bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been performed in an attempt to increase healing rates of the affected cases. This literature review aimed to identify clinical studies of surgical management of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in order to assess their surgical treatment modalities, outcome and the follow-up.

Methods: A search in the PubMed (Medline) database using specific terms and/or phrases as "bisphosphonate-related osteonecrosis" or "jaw osteonecrosis", and "surgical treatment" or "surgical management" was conducted in order to identify clinical trials and cases of surgical treatment of BRONJ. The review search covered the time period from 2004 to 2014. All studies identified in the search were selected according to the inclusion criteria. Relevant information was recorded according to the following items: author, year, number of patients, BRONJ clinical stage, surgical treatment modality, clinical success, and follow-up.

Results: The initial database search yielded 345 titles. After filtering, 67 abstracts were selected culminating in 67 full text articles. A variety of surgical approach was found in this review: debridement, sequestrectomy bone resection, and bone reconstruction. Adjunctive therapies included hyperbaric oxygen, laser therapy, growth factors, and ozone.

Conclusion: Although there are many indexed studies about BRONJ, well-documented reports concerning surgical therapeutically techniques are scarce, resulting from a lack of well-established protocols. Considerable differences were found regarding sample size, surgical treatment modalities and outcomes. Clinical studies with larger number of patients and longer follow-up are required to provide best information for each surgical treatment modality and its outcomes.

Keywords: Bisphosphonate-related osteonecrosis of the jaws; Surgical approach; Surgical management; Surgical treatment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Oral Maxillofac Surg. 2009 May;67(5):943-50 - PubMed
    1. J Oral Maxillofac Surg. 2007 Mar;65(3):415-23 - PubMed
    1. Aust Dent J. 2012 Jun;57(2):227-30 - PubMed
    1. J Craniofac Surg. 2011 Nov;22(6):2185-90 - PubMed
    1. Photomed Laser Surg. 2012 Jan;30(1):5-13 - PubMed

Publication types

MeSH terms

LinkOut - more resources