Allergen immunotherapy for the prevention of allergic disease: protocol for a systematic review

Sangeeta Dhami¹, Ulugbek Nurmatov², Susanne Halken³, Moises A Calderón⁴, Antonella Muraro⁵, Graham Roberts^{6

7}, George Du Toit⁸, Jörg Kleine-Tebbe⁹, Desiree Larenas-Linnemann¹⁰, Susanne Lau¹¹, Paolo Maria Matricardi¹², Giovanni Pajno¹³, Nikolaos G Papadopoulos^{14

15}, Oliver Pfaar¹⁶, Dermot Ryan¹⁷, Alexandra F Santos¹⁸, Frans Timmermanns¹⁹, Ulrich Wahn²⁰, Aziz Sheikh¹⁷

Affiliations

¹ Evidence-Based Health Care Ltd, Edinburgh, UK.
² Systematic Review at Decision Resources Group Abacus International, Oxford, UK.
³ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
⁴ Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.
⁵ The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.
⁶ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁷ Faculty of Medicine, University of Southampton, Southampton, UK.
⁸ Department of Paediatric Allergy, MRC & Asthma Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King's College London and St Thomas NHS Foundation trust, London, UK.
⁹ Allergy & Asthma Center Westend, Berlin, Germany.
¹⁰ Hospital Medica Sur, Mexico City, Mexico.
¹¹ Clinic for Pediatric Pneumonology and Immunology, Charité Medical University, Berlin, Germany.
¹² AG Molecular Allergology and Immunomodulation, Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
¹³ Department of Pediatrics, University of Messina, Messina, Italy.
¹⁴ Institute of Human Development, University of Manchester, Manchester, UK.
¹⁵ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
¹⁶ Department of Otorhinolaryngology, Head and Neck Surgery University Hospital, Mannheim and Center for Rhinology and Allergology, Wiesbaden, Germany.
¹⁷ University of Edinburgh, Edinburgh, UK.
¹⁸ Department of Paediatric Allergy, Division of Asthma Allergy and Lung Biology, King's College London/Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
¹⁹ Netherlands Anaphylaxis Networks, Netherlands, Netherlands.
²⁰ Clinic for Pediatric Pneumonology and Immunology, Charité University Berlin, Berlin, Germany.

PMID: 26660074
DOI: 10.1111/pai.12524

Allergen immunotherapy for the prevention of allergic disease: protocol for a systematic review

Sangeeta Dhami et al. Pediatr Allergy Immunol. 2016 May.

. 2016 May;27(3):236-41.

doi: 10.1111/pai.12524. Epub 2016 Jan 21.

Authors

Affiliations

¹ Evidence-Based Health Care Ltd, Edinburgh, UK.
² Systematic Review at Decision Resources Group Abacus International, Oxford, UK.
³ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
⁴ Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.
⁵ The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.
⁶ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁷ Faculty of Medicine, University of Southampton, Southampton, UK.
⁸ Department of Paediatric Allergy, MRC & Asthma Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King's College London and St Thomas NHS Foundation trust, London, UK.
⁹ Allergy & Asthma Center Westend, Berlin, Germany.
¹⁰ Hospital Medica Sur, Mexico City, Mexico.
¹¹ Clinic for Pediatric Pneumonology and Immunology, Charité Medical University, Berlin, Germany.
¹² AG Molecular Allergology and Immunomodulation, Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
¹³ Department of Pediatrics, University of Messina, Messina, Italy.
¹⁴ Institute of Human Development, University of Manchester, Manchester, UK.
¹⁵ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
¹⁶ Department of Otorhinolaryngology, Head and Neck Surgery University Hospital, Mannheim and Center for Rhinology and Allergology, Wiesbaden, Germany.
¹⁷ University of Edinburgh, Edinburgh, UK.
¹⁸ Department of Paediatric Allergy, Division of Asthma Allergy and Lung Biology, King's College London/Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
¹⁹ Netherlands Anaphylaxis Networks, Netherlands, Netherlands.
²⁰ Clinic for Pediatric Pneumonology and Immunology, Charité University Berlin, Berlin, Germany.

PMID: 26660074
DOI: 10.1111/pai.12524

Abstract

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Prevention of Allergic Disease. We seek to critically assess the effectiveness, cost-effectiveness, and safety of AIT in the prevention of allergic disease.

Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesized.

Discussion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.

Keywords: allergen immunotherapy; allergic diseases; allergy; atopic; prevention; sensitization.

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Allergen immunotherapy for the prevention of allergic disease: protocol for a systematic review

Affiliations

Allergen immunotherapy for the prevention of allergic disease: protocol for a systematic review

Authors

Affiliations

Abstract

MeSH terms

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LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical