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Randomized Controlled Trial
. 2016 May;23(3):449-55.
doi: 10.1093/jamia/ocv158. Epub 2015 Dec 11.

The feasibility of text reminders to improve medication adherence in adolescents with asthma

Kevin B Johnson  1 , Barron L Patterson  2 , Yun-Xian Ho  3 , Qingxia Chen  4 , Hui Nian  5 , Coda L Davison  3 , Jason Slagle  6 , Shelagh A Mulvaney  7
Affiliations
Randomized Controlled Trial

The feasibility of text reminders to improve medication adherence in adolescents with asthma

Kevin B Johnson et al. J Am Med Inform Assoc. 2016 May.

Abstract

Objective: Personal health applications have the potential to help patients with chronic disease by improving medication adherence, self-efficacy, and quality of life. The goal of this study was to assess the impact of MyMediHealth (MMH) - a website and a short messaging service (SMS)-based reminder system - on medication adherence and perceived self-efficacy in adolescents with asthma.

Methods: We conducted a block-randomized controlled study in academic pediatric outpatient settings. There were 98 adolescents enrolled. Subjects who were randomized to use MMH were asked to create a medication schedule and receive SMS reminders at designated medication administration times for 3 weeks. Control subjects received action lists as a part of their usual care. Primary outcome measures included MMH usage patterns and self-reports of system usability, medication adherence, asthma control, self-efficacy, and quality of life.

Results: Eighty-nine subjects completed the study, of whom 46 were randomized to the intervention arm. Compared to controls, we found improvements in self-reported medication adherence (P = .011), quality of life (P = .037), and self-efficacy (P = .016). Subjects reported high satisfaction with MMH; however, the level of system usage varied widely, with lower use among African American patients.

Conclusions: MMH was associated with improved medication adherence, perceived quality of life, and self-efficacy.Trial Registration This project was registered under http://clinicaltrials.gov/ identifier NCT01730235.

Keywords: adherence; adolescent; asthma; biomedical informatics; clinical trial; mHealth; mobile technology; personal health records.

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Figures

Figure 1:
Figure 1:
MyMediHealth study eligibility and enrollment overview.
Figure 2:
Figure 2:
Control versus Intervention group perceptions of medication adherence, self-efficacy, and quality of life.
See this image and copyright information in PMC

References

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