Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine

Ted M Burns¹, Gordon A Smith², Jeffrey A Allen³, Anthony A Amato⁴, W David Arnold⁵, Richard Barohn⁶, Michael Benatar⁷, Shawn J Bird⁸, Mark Bromberg², Nizar Chahin⁹, Emma Ciafaloni¹⁰, Jeffrey A Cohen¹¹, Andrea Corse¹², Brian A Crum¹³, William S David¹⁴, Elliot Dimberg¹⁵, Eduardo A De Sousa¹⁶, Peter D Donofrio¹⁷, P James B Dyck¹³, Andrew G Engel¹³, Erik R Ensrud¹⁸, Mark Ferrante¹⁹, Miriam Freimer²⁰, Karissa L Gable²¹, Summer Gibson², James M Gilchrist²², Jonathan M Goldstein²³, Clifton L Gooch²⁴, Brent P Goodman²⁵, Dmitri Gorelov²⁶, Sidney M Gospe Jr²⁷, Namita A Goyal²⁸, Amanda C Guidon¹⁴, Jeffrey T Guptill²¹, Laurie Gutmann²⁹, Ludwig Gutmann²⁹, Kelly Gwathmey¹, Yadollah Harati³⁰, C Michel Harper Jr¹³, Michael K Hehir³¹, Lisa D Hobson-Webb²¹, James F Howard Jr³², Carlayne E Jackson³³, Nicholas Johnson², Sarah M Jones¹, Vern C Juel²¹, Henry J Kaminski³⁴, Chafic Karam³², Kathleen D Kennelly¹⁵, Sami Khella⁸, Julie Khoury³⁵, John C Kincaid³⁶, John T Kissel²⁰, Noah Kolb², David Lacomis³⁷, Shafeeq Ladha³⁸, Daniel Larriviere³⁹, Richard A Lewis⁴⁰, Yuebing Li⁴¹, William J Litchy¹³, Eric Logigian¹⁰, Jau-Shin Lou⁴², Daniel J L MacGowen⁴³, Ricardo Maselli⁴⁴, Janice M Massey²¹, Michelle L Mauermann¹³, Katherine D Mathews²⁹, Matthew N Meriggioli⁴⁵, Robert G Miller⁴⁶, Joon-Shik Moon¹⁶, Tahseen Mozaffar²⁸, Sharon P Nations⁴⁷, Richard J Nowak⁴⁸, Lyle W Ostrow¹², Robert M Pascuzzi³⁶, Amanda Peltier¹⁷, Katherine Ruzhansky⁴⁹, David P Richman⁴⁴, Mark A Ross²⁵, Devon I Rubin¹⁵, James A Russell⁵⁰, George M Sachs⁵¹, Mohammad Kian Salajegheh⁴, David S Saperstein⁵², Stephen Scelsa⁴³, Duygu Selcen¹³, Aziz Shaibani⁵³, Perry B Shieh⁵⁴, Nicholas J Silvestri⁵⁵, J Rob Singleton², Benn E Smith²⁵, Yuen T So⁵⁶, Guillermo Solorzano¹, Eric J Sorenson¹³, Jayashri Srinivasen⁵⁰, Jinny Tavee⁴¹, Rabi Tawil¹⁰, Pariwat Thaisetthawatkul⁵⁷, Charles Thornton¹⁰, Jaya Trivedi⁴⁸, Steven Vernino⁴⁷, Annabel K Wang⁵⁸, Tyler A Webb¹⁶, Michael D Weiss²⁷, Anthony J Windebank¹³, Gil I Wolfe⁵⁵

Affiliations

¹ Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.
² Department of Neurology University of Utah, Salt Lake City, Utah, USA.
³ Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁵ Department of Neurology and Physical Medicine and Rehabilitation, Ohio State University, Columbus, Ohio, USA.
⁶ Department of Neurology, University of Kansas, Kansas City, Kansas, USA.
⁷ Department of Neurology, University of Miami, Miami, Florida, USA.
⁸ Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁹ Department of Neurology, University of Connecticut, Farmington, Connecticut, USA.
¹⁰ Department of Neurology, University of Rochester, Rochester, New York, USA.
¹¹ Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
¹² Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹³ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁴ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹⁵ Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
¹⁶ Department of Neurology, University of Oklahoma, Oklahoma City, Oklahoma, USA.
¹⁷ Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
¹⁸ Department of Neurology, Boston Veterans Affairs, Boston, Massachusetts, USA.
¹⁹ Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
²⁰ Department of Neurology, Ohio State University, Columbus, Ohio, USA.
²¹ Department of Neurology, Duke University, Durham, North Carolina, USA.
²² Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
²³ Department of Neurology, Hospital for Special Surgery, New York, New York, USA.
²⁴ Department of Neurology, University of South Florida, Tampa, Florida, USA.
²⁵ Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
²⁶ Crystal Run Healthcare, Middletown, New York, USA.
²⁷ Department of Neurology, University of Washington, Seattle, Washington, USA.
²⁸ Department of Neurology, University of California Irvine, Irvine, California, USA.
²⁹ Division of Neurology, University of Iowa, Iowa City, Iowa, USA.
³⁰ Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
³¹ Department of Neurology, University of Vermont, Burlington, Vermont, USA.
³² Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
³³ Department of Neurology and Otolaryngology, University of Texas Health Science Center, San Antonio, Texas, USA.
³⁴ Department of Neurology, George Washington University, Washington, DC, USA.
³⁵ Department of Neurology, Oregon Health Science University, Portland, Oregon, USA.
³⁶ Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
³⁷ Department of Neurology and Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
³⁸ Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
³⁹ Department of Neurology, Ochsner Neuroscience Institute, New Orleans, Louisiana, USA.
⁴⁰ Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁴¹ Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA.
⁴² Department of Neurology, University of North Dakota, Sanford Health, Fargo, North Dakota, USA.
⁴³ Department of Neurology, Department of Neurology, Mount Sinai Beth Israel Hospital, New York, New York, USA.
⁴⁴ Department of Neurology, University of California, Davis, Sacramento, California, USA.
⁴⁵ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
⁴⁶ Department of Neurosciences, California Pacific Medical Center, San Francisco, California, USA.
⁴⁷ Department of Neurology and Neurotherapeutics, University Texas Southwestern, Dallas, Texas, USA.
⁴⁸ Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
⁴⁹ Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
⁵⁰ Department of Neurology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
⁵¹ Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
⁵² Phoenix Neurological Associates, Phoenix, Arizona, USA.
⁵³ Nerve and Muscle Center of Texas, Houston, Texas, USA.
⁵⁴ Department of Neurology, University of California at Los Angeles, Los Angeles, California, USA.
⁵⁵ Department of Neurology, University of Buffalo, Buffalo, New York, USA.
⁵⁶ Department of Neurology, Stanford University, Palo Alto, California, USA.
⁵⁷ Department of Neurology, University of Nebraska, Omaha, Nebraska, USA.
⁵⁸ Department of Neurology, Veterans Affairs Long Beach Healthcare System, Long Beach, California, USA.

PMID: 26662952
DOI: 10.1002/mus.25009

Editorial

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine

Ted M Burns et al. Muscle Nerve. 2016 Feb.

. 2016 Feb;53(2):165-8.

doi: 10.1002/mus.25009. Epub 2015 Dec 21.

Authors

Affiliations

¹ Department of Neurology, University of Virginia, Charlottesville, Virginia, 22908, USA.
² Department of Neurology University of Utah, Salt Lake City, Utah, USA.
³ Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
⁵ Department of Neurology and Physical Medicine and Rehabilitation, Ohio State University, Columbus, Ohio, USA.
⁶ Department of Neurology, University of Kansas, Kansas City, Kansas, USA.
⁷ Department of Neurology, University of Miami, Miami, Florida, USA.
⁸ Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁹ Department of Neurology, University of Connecticut, Farmington, Connecticut, USA.
¹⁰ Department of Neurology, University of Rochester, Rochester, New York, USA.
¹¹ Department of Neurology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
¹² Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹³ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁴ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹⁵ Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
¹⁶ Department of Neurology, University of Oklahoma, Oklahoma City, Oklahoma, USA.
¹⁷ Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
¹⁸ Department of Neurology, Boston Veterans Affairs, Boston, Massachusetts, USA.
¹⁹ Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
²⁰ Department of Neurology, Ohio State University, Columbus, Ohio, USA.
²¹ Department of Neurology, Duke University, Durham, North Carolina, USA.
²² Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
²³ Department of Neurology, Hospital for Special Surgery, New York, New York, USA.
²⁴ Department of Neurology, University of South Florida, Tampa, Florida, USA.
²⁵ Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
²⁶ Crystal Run Healthcare, Middletown, New York, USA.
²⁷ Department of Neurology, University of Washington, Seattle, Washington, USA.
²⁸ Department of Neurology, University of California Irvine, Irvine, California, USA.
²⁹ Division of Neurology, University of Iowa, Iowa City, Iowa, USA.
³⁰ Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
³¹ Department of Neurology, University of Vermont, Burlington, Vermont, USA.
³² Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
³³ Department of Neurology and Otolaryngology, University of Texas Health Science Center, San Antonio, Texas, USA.
³⁴ Department of Neurology, George Washington University, Washington, DC, USA.
³⁵ Department of Neurology, Oregon Health Science University, Portland, Oregon, USA.
³⁶ Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
³⁷ Department of Neurology and Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
³⁸ Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
³⁹ Department of Neurology, Ochsner Neuroscience Institute, New Orleans, Louisiana, USA.
⁴⁰ Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁴¹ Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA.
⁴² Department of Neurology, University of North Dakota, Sanford Health, Fargo, North Dakota, USA.
⁴³ Department of Neurology, Department of Neurology, Mount Sinai Beth Israel Hospital, New York, New York, USA.
⁴⁴ Department of Neurology, University of California, Davis, Sacramento, California, USA.
⁴⁵ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
⁴⁶ Department of Neurosciences, California Pacific Medical Center, San Francisco, California, USA.
⁴⁷ Department of Neurology and Neurotherapeutics, University Texas Southwestern, Dallas, Texas, USA.
⁴⁸ Department of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
⁴⁹ Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
⁵⁰ Department of Neurology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
⁵¹ Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
⁵² Phoenix Neurological Associates, Phoenix, Arizona, USA.
⁵³ Nerve and Muscle Center of Texas, Houston, Texas, USA.
⁵⁴ Department of Neurology, University of California at Los Angeles, Los Angeles, California, USA.
⁵⁵ Department of Neurology, University of Buffalo, Buffalo, New York, USA.
⁵⁶ Department of Neurology, Stanford University, Palo Alto, California, USA.
⁵⁷ Department of Neurology, University of Nebraska, Omaha, Nebraska, USA.
⁵⁸ Department of Neurology, Veterans Affairs Long Beach Healthcare System, Long Beach, California, USA.

PMID: 26662952
DOI: 10.1002/mus.25009

No abstract available

PubMed Disclaimer

Comment in

A response to a recent editorial by concerned physicians on 3,4-diaminopyridine.
McEnany PJ. McEnany PJ. Muscle Nerve. 2017 Jan;55(1):138. doi: 10.1002/mus.25437. Epub 2016 Nov 16. Muscle Nerve. 2017. PMID: 27756108 No abstract available.
Reply.
Burns TM, Smith GA. Burns TM, et al. Muscle Nerve. 2017 Jan;55(1):138-140. doi: 10.1002/mus.25436. Epub 2016 Nov 16. Muscle Nerve. 2017. PMID: 27756114 No abstract available.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine

Affiliations

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine

Authors

Affiliations

Comment in

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources