Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Oct;71(4):340-4.
doi: 10.1016/j.mjafi.2015.06.023. Epub 2015 Aug 31.

Incidence and clinical implication of TT virus in patients with hepatitis and its frequency in blood donors in India

S K Magu  1 , A T Kalghatgi  2 , M R Bhagat  3
Affiliations

Incidence and clinical implication of TT virus in patients with hepatitis and its frequency in blood donors in India

S K Magu et al. Med J Armed Forces India. 2015 Oct.

Abstract

Background: Transfusion Transmitted Virus (TTV), also known as Torque Teno Virus is a new novel viral agent which appears to correlate with some acute and chronic hepatitis cases and may produce liver damage under specific circumstances. Aim of this study was to detect TT virus by real-time PCR, study its clinical implications and effects of its co-infection in HBV and HCV chronic liver diseases.

Methods: The study population comprised 50 acute hepatitis, 50 chronic hepatitis patients and 100 voluntary blood donors. All samples were tested for serum bilirubin, AST, ALT and alkaline phosphatase levels and for all available viral markers for hepatitis. The detection of TT viral genome was carried out by real-time PCR using TTV sequences as reported by Takahashi et al with modifications on the basis of database of the DDBJ/EMBL/GenBank (GenBank accession no. AB008394).

Result: Serum was positive for TTV in 72% of volunteer blood donors, 77.4% (24/31) of hepatitis A cases, 87.6% (36/41) of HBV-positive, 77% (10/13) of HCV-positive, and 92.8% (13/14) of non-B, non-C cases. Co-infection of TTV with other hepatitis viruses was detected in some patients.

Conclusion: TTV is a frequent virus detected in patients with various types of viral hepatitis, in cases of hepatitis without obvious viral agent, and from the healthy population in India. Rate of TTV was found to be significantly higher (92.8%) for Non A-E hepatitis group.

Keywords: Hepatitis; Real-time PCR; TT virus; Transfusion.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Clinical chemistry profile in various groups.
Fig. 2
Fig. 2
Positivity of viral markers for various hepatitis viruses.
Fig. 3
Fig. 3
Co-infection of TTV with other hepatitis viruses.
Fig. 4
Fig. 4
Comparative study of liver function among blood donors and patient groups with positive and negative Transfusion Transmitted Virus (TTV) viraemia.
See this image and copyright information in PMC

References

    1. Shigeo H. TTV, a new human virus with single stranded circular DNA genome. Rev Med Virol. 2002;12:151–158. - PubMed
    1. Nishizawa T., Okamoto H., Konishi K., Yoshizawa H., Miyakawa Y., Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun. 1997;241:92–97. - PubMed
    1. Abe K., Inami T., Asano K. TT virus infection is widespread in the general populations from different geographic regions. J Clin Microbiol. 1999;3718:2703–2705. - PMC - PubMed
    1. Asim M., Singla R., Gupta R.K., Kar P. Clinical & molecular characterization of human TT virus in different liver diseases. Indian J Med Res. Apr 2010;131:545–554. - PubMed
    1. Chattopadhyay S., Rao S., Das B.C., Singh N.P., Kar P. Prevalence of transfusion-transmitted virus infection in patients on maintenance hemodialysis from New Delhi, India. Hemodial Int. 2005;9:362–366. - PubMed

LinkOut - more resources