Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Oct;71(4):373-6.
doi: 10.1016/j.mjafi.2014.08.013. Epub 2014 Nov 6.

Trichosporon asahii urinary tract infection in immunocompetent patients

Inam Danish Khan  1 , Ajay Kumar Sahni  2 , Atoshi Basu  3 , Suboohi Haleem  4
Affiliations

Trichosporon asahii urinary tract infection in immunocompetent patients

Inam Danish Khan et al. Med J Armed Forces India. 2015 Oct.

Abstract

Trichosporonosis is an emerging infection predominantly caused by Trichosporon asahii which is a ubiquitous and exclusively anamorphic yeast. T. asahii urinary tract infection is rare and remains scantily reported. T. asahii was isolated from urine of two immunocompetent patients who were receiving in-patient treatment for multiple comorbidities. T. asahii was identified phenotypically by a combination of manual and automated systems. Antifungal susceptibility done by E-test revealed multiresistance with preserved susceptibility to voriconazole. The ubiquity and biofilm formationposes difficulty in establishing pathogenicity and delineating environmental or nosocomial infections. Risk factors such as prolonged multiple antimicrobials, indwelling catheter and comorbidities such as anemia and hypoalbuminemia may be contributory to the establishment of a nosocomial opportunistic T. asahii infection. Dedicated efforts targeted at infection control are needed to optimize management and control of Trichosporon infections.

Keywords: Antifungal multiresistance; Nosocomial opportunistic infection; Trichosporon asahii.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Trichosporon asahii on CLED agar after overnight incubation.
Fig. 2
Fig. 2
Gram stain of Trichosporon asahii showing budding yeasts and barrel shaped arthroconidia.
Fig. 3
Fig. 3
Antifungal susceptibility of Trichosporon asahii through E-test showing an MIC of 3 μg/ml.
See this image and copyright information in PMC

References

    1. Dua V., Yadav S.P., Oberoi J., Sachdeva A. Successful treatment of Trichosporon asahii infection with voriconazole after bone marrow transplant. J Pediatr Hematol Oncol. 2013;35(3):237–238. http://www.ncbi.nlm.nih.gov/pubmed/23211690 - PubMed
    1. Cawley M.J., Braxton G.R., Haith L.R., Reilly K.J., Guilday R.E., Patton M.L. Trichosporon beigelii infection: experience in a regional burn center. Burns. 2000 Aug;26(5):483–486. http://www.ncbi.nlm.nih.gov/pubmed/10812273 - PubMed
    1. Vashishtha V.M., Mittal A., Garg A. A fatal outbreak of Trichosporon asahii sepsis in a neonatal intensive care unit. Indian Pediatr. 2012 Sep;49(9):745–747. http://www.ncbi.nlm.nih.gov/pubmed/23024079 - PubMed
    1. Bayramoglu G., Sonmez M., Tosun I., Aydin K., Aydin F. Breakthrough Trichosporon asahii fungemia in neutropenic patient with acute leukemia while receiving caspofungin. Infection. 2008:3668–3670. http://www.ncbi.nlm.nih.gov/pubmed/17882360 - PubMed
    1. Sood S., Pathak D., Sharma R., Rishi S. Urinary tract infection by Trichosporon asahii. Indian J Med Microbiol. 2006 Oct;24(4):294–296. http://www.ncbi.nlm.nih.gov/pubmed/17185852 - PubMed

LinkOut - more resources