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Review
. 2015 Sep 18:22:53.
doi: 10.11604/pamj.2015.22.53.6563. eCollection 2015.

Penile cancer: about ten cases at the University Hospital of Rabat, review of the literature

Amine Slaoui  1 , Youness Jabbour  1 , Anouar El Ghazoui  1 , Tarik Karmouni  1 , Khalid Elkhader  1 , Abdelatif Koutani  1 , Ahmed Ibn Attaya  1
Affiliations
Review

Penile cancer: about ten cases at the University Hospital of Rabat, review of the literature

Amine Slaoui et al. Pan Afr Med J. .

Abstract

The aim of our study was to report the status of penile cancer sites in the urology department at the University Hospital of Rabat and evaluate long-term results of surgical treatment of this cancer.

Patients and methods: Between 1989 and 2015, 10 patients were treated for penile cancer. 10 cases were retrospectively reviewed and the following data were recorded: mode of revelation, seat, staging, TNM stage, treatment, evolution and survival. The mean age of patients was 58,1 years (48-81 years). All patients had squamous cell carcinoma of the penis. Six patients had a partial amputation of the penis, and three patients underwent total amputation. The median size of the lesion was 4.25 cm (1.5-8 cm). All tumors had a distal seat (gland- Furrow balanopreputial), 8 were localized and non-invasive (PT1 - PT2) and 2 had infiltrated the urethra (PT3). Four patients had lymph node localization. A single bilateral lymphadenectomy was performed and was positive only on one side, with a node <3 cm and no extracapsular extension. Two patients were referred for chemotherapy, a neoadjuvant referred to basic (Bleomycin - Methotrexate, Cisplatin) the other in a palliative goal. Median follow-up was 42 months (6 -72mois). Four patients died, one of which was presented immediately with metastatic mode. Six patients were alive at last node or local recurrence negative. Cancer of the penis seems rare in Morocco. His oncologic and functional outcomes (sexual and urinary) depend on the precocity of the treatment. The surgery of lymph node resection with lymphadenectomy remains the reference treatment.

Keywords: Partial penectomy; Penile Cancer; lymphadenectomy; total penectomy.

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Figures

Figure 1
Figure 1
Cauliflower appearance of the tumor
Figure 2
Figure 2
Infiltration of the urethra (HEx100)
Figure 3
Figure 3
Appearance after total penectomy
Figure 4
Figure 4
Resected specimen
Figure 5
Figure 5
Perineal urethrostomy
Figure 6
Figure 6
Dyskeratotic cells with tumor proliferation (HEx400)
Figure 7
Figure 7
Cutaneous coatings adjacent to the tumor showing parakeratosis. Koilocytespresence (HEx200)
See this image and copyright information in PMC

References

    1. Mottet N, Avances C, Bastide C, Culine S, Ibora F, Kouri G, et al. Penile tumors (Tumeurs du penis) Prog urol. 2004;14(Suppl 1):903, 905–11. - PubMed
    1. Cubilla AL, Lloveras B, Alemany L, et al. Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. Am J Surg Pathol. 2012 Jun;36(6):869–75. - PubMed
    1. Chaux A, Netto GJ, Rodriguez IM, et al. Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma. World J Urol. 2013 Aug;31(4):861–7. - PMC - PubMed
    1. Stankiewicz E, Kudahetti SC, Prowse DM, et al. HPV infection and immunochemical detection of cell- cycle markers in verrucous carcinoma of the penis. Mod Pathol. 2009 Sep;22(9):1160–8. - PubMed
    1. Muñoz N, Castelisague X, de Gonzalez AB, et al. HPV in the etiology of human cancer. Vaccine. 2006 Aug;24(Suppl 3):S3/1–10. - PubMed

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