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Review
. 2015 Mar 16:2:13.
doi: 10.3389/fcvm.2015.00013. eCollection 2015.

Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes

Gabriele Giacomo Schiattarella  1 , Fabio Magliulo  1 , Fabio Cattaneo  2 , Giuseppe Gargiulo  1 , Anna Sannino  1 , Anna Franzone  3 , Marco Oliveti  1 , Cinzia Perrino  1 , Bruno Trimarco  1 , Giovanni Esposito  1
Affiliations
Review

Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes

Gabriele Giacomo Schiattarella et al. Front Cardiovasc Med. .

Abstract

Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membrane receptors (7TMRs), also called G-protein-coupled receptors (GPCRs), in HF. Moreover, we will discuss the current knowledge on the potential mirroring of 7TMR signaling between circulating blood leukocytes and the heart, and the related future possibilities in the management of HF patients.

Keywords: cardiac remodeling; heart failure; leukocytes; seven trans-membrane receptors.

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Figures

Figure 1
Figure 1
The “paradigm” of lymphocyte mirroring of heart signals.
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