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. 2015:2015:185387.
doi: 10.1155/2015/185387. Epub 2015 Nov 19.

Molecular Characterization of Candida africana in Genital Specimens in Shanghai, China

Yang Hu  1 , Aihua Yu  1 , Xiangming Chen  1 , Guojiang Wang  1 , Xiaobo Feng  2
Affiliations

Molecular Characterization of Candida africana in Genital Specimens in Shanghai, China

Yang Hu et al. Biomed Res Int. 2015.

Abstract

Candida africana, an emerging yeast pathogen, is closely related to Candida albicans and most commonly involved in vulvovaginal candidiasis (VVC). However, its prevalence in candidal balanoposthitis is still unclear. In this study, the prevalence of C. africana in both candidal balanoposthitis and VVC in a sexually transmitted diseases (STD) clinic in Shanghai, China, was analyzed, and the molecular characterization and susceptible profiles of C. africana isolates were investigated. As results, C. africana was only isolated in 5 out of 79 (6.3%) cases of candidal balanoposthitis rather than cases with vulvovaginal candidiasis. Among them, 4 out of 5 isolates share the same genotype of DST 782 with an isolate from vaginal swab in Japan published previously. All C. africana isolates were susceptible to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and micafungin.

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Figures

Figure 1
Figure 1
Agarose gel electrophoresis of PCR products. Species or variety is depicted in brackets. Lanes: M, DL2000 ladder. 1, ATCC10231 (C. albicans). 2, Caf1 (C. africana). 3, CD36 (C. dubliniensis). 4, XH455 (C. africana). 5, XH824 (C. africana). 6, XH520 (C. africana). 7, XH644 (C. africana). 8, XH874 (C. africana). 9, negative control.
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