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Comment
. 2015 Dec 14;212(13):2186.
doi: 10.1084/jem.21213insight3.

An autoimmune "attack" on melanocytes triggers psoriasis and cellular hyperplasia

James G Krueger  1
Affiliations
Comment

An autoimmune "attack" on melanocytes triggers psoriasis and cellular hyperplasia

James G Krueger. J Exp Med. .
No abstract available

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Figures

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Insight from James Krueger
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In psoriasis, CD8+ T cells recognize ADAMTSL5 as an autoantigen presented by melanocytes in HLA-C*06:02 molecules. ADAMTSL5 stimulation triggers the psoriasis signature cytokine, IL-17A.
See this image and copyright information in PMC

Comment on

  • Melanocyte antigen triggers autoimmunity in human psoriasis.
    Arakawa A, Siewert K, Stöhr J, Besgen P, Kim SM, Rühl G, Nickel J, Vollmer S, Thomas P, Krebs S, Pinkert S, Spannagl M, Held K, Kammerbauer C, Besch R, Dornmair K, Prinz JC. Arakawa A, et al. J Exp Med. 2015 Dec 14;212(13):2203-12. doi: 10.1084/jem.20151093. Epub 2015 Nov 30. J Exp Med. 2015. PMID: 26621454 Free PMC article.

References

    1. Arakawa, A., et al. . 2015. J. Exp. Med. 10.1084/jem.20151093 - DOI