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. 2015 Dec 14;60(3):1883-7.
doi: 10.1128/AAC.02101-15.

Risk Factors and Outcomes for Intestinal Carriage of AmpC-Hyperproducing Enterobacteriaceae in Intensive Care Unit Patients

Simon Poignant  1 , Jérôme Guinard  2 , Aurélie Guigon  2 , Laurent Bret  2 , Didier-Marc Poisson  2 , Thierry Boulain  1 , François Barbier  3
Affiliations

Risk Factors and Outcomes for Intestinal Carriage of AmpC-Hyperproducing Enterobacteriaceae in Intensive Care Unit Patients

Simon Poignant et al. Antimicrob Agents Chemother. .

Abstract

In a cohort of 1,209 intensive care unit (ICU) patients, the prevalence of intestinal colonization with high-level expressed AmpC cephalosporinase-producing Enterobacteriaceae (HLAC-PE) rose steadily from 2% at admission to 30% in patients with lengths of stay (LOS) exceeding 4 weeks. In multivariate analysis, LOS was the main predictor of carriage acquisition after adjustment on antimicrobial exposure. HLAC-PE infection occurred in 15% of carriers. Carriage and infection were associated with a marked increase in carbapenem consumption.

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Figures

FIG 1
FIG 1
Observed rates of intestinal carriage of high-level AmpC cephalosporinase-producing Enterobacteriaceae isolates in critically ill patients according to their length of stay in the intensive care unit (days). P value for trend was <0.0001 (chi-square test). Bars indicate 95% confidence intervals.
See this image and copyright information in PMC

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