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Review
. 2016 Jan;16(1):35-42.
doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15.

DNA repair, genome stability and cancer: a historical perspective

Penny A Jeggo  1 , Laurence H Pearl  1 , Antony M Carr  1
Affiliations
Review

DNA repair, genome stability and cancer: a historical perspective

Penny A Jeggo et al. Nat Rev Cancer. 2016 Jan.

Abstract

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.

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