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. 2016 Jan;137(1):e20152480.
doi: 10.1542/peds.2015-2480. Epub 2015 Dec 14.

Nonmedical Use of Prescription Drugs and Sexual Risk Behaviors

Heather B Clayton  1 , Richard Lowry  2 , Euna August  3 , Sherry Everett Jones  2
Affiliations

Nonmedical Use of Prescription Drugs and Sexual Risk Behaviors

Heather B Clayton et al. Pediatrics. 2016 Jan.

Abstract

Background: Substance use is associated with sexual risk behaviors among youth, but little is known about whether nonmedical prescription drug use, an increasingly common behavior, is associated with sexual risk behaviors.

Methods: Data from the 2011 and 2013 national Youth Risk Behavior Surveys, cross-sectional surveys conducted among nationally representative samples of students in grades 9 to 12 were combined (n = 29,008) to examine the association between ever taking prescription drugs without a doctor's prescription and sexual risk behaviors (ever having sexual intercourse, current sexual activity, lifetime number of sexual partners, condom use, and alcohol or drug use before last sexual intercourse). Using logistic regression models (adjusted for sex, race/ethnicity, grade, ever injection drug use, and use of alcohol, marijuana, heroin, cocaine, methamphetamines, ecstasy, and inhalants), we estimated adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs).

Results: Nonmedical use of prescription drugs (NMUPD) was associated with ever having sexual intercourse (aPR 1.16 [95% CI 1.11-1.22]), being currently sexually active (1.26 [1.20-1.33]), having ≥ 4 lifetime sexual partners (1.45 [1.34-1.57]), drinking alcohol or using drugs before last sexual intercourse (1.32 [1.17-1.48]), and not using a condom at last sexual intercourse (1.14 [1.05-1.23]). As the frequency of NMUPD increased, the association between NMUPD and each of the sexual risk behaviors increased in strength, suggesting a dose-response relationship.

Conclusions: NMUPD is associated with sexual behaviors that put high school students at risk for sexually transmitted infections. These findings can be used to inform clinical and school-based interventions developed to reduce drug use and sexually transmitted infections.

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Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.

Comment in

References

    1. Warner M, Hedegaard H, Chen L. Trends in drug-poisoning deaths involving opioid analgesics and heroin: United States, 1999-2012. NCHS Health E-Stat, Updated December 2, 2014. Atlanta, GA: Centers for Disease Control and Prevention. Available at: www.cdc.gov/nchs/data/hestat/drug_poisoning/drug_poisoning.htm. Accessed August 10, 2015
    1. Substance Abuse and Mental Health Services Administration . Highlights of the 2011 Drug Abuse Warning Network (DAWN) Findings on Drug-Related Emergency Department Visits. The Dawn Report. Rockville, MD: US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration; 2013. Available at: www.samhsa.gov/data/2k13/DAWN127/sr127-DAWN-highlights.htm. Accessed October 26, 2015 - PubMed
    1. Centers for Disease Control and Prevention . Youth risk behavior surveillance – United States, 2013. Surveill Summ. 2014;63(4):1–168 - PubMed
    1. Miech RA, Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future: National Survey Results on Drug Use 1975-2014. Volume 1: Secondary School Students. Available at: www.monitoringthefuture.org//pubs/monographs/mtf-vol1_2014.pdf. Accessed August 10, 2015
    1. McCabe SE, Boyd CJ, Teter CJ. Illicit use of opioid analgesics by high school seniors. J Subst Abuse Treat. 2005;28(3):225–230 - PubMed