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Review
. 2015 Oct;10(10):1671-82.

Bioactive Secondary Metabolites Produced by the Fungal Endophytes of Conifers

Andrea A Stierle, Donald B Stierle
Review

Bioactive Secondary Metabolites Produced by the Fungal Endophytes of Conifers

Andrea A Stierle et al. Nat Prod Commun. 2015 Oct.

Abstract

This is a review of bioactive secondary metabolites isolated from conifer-associated endophytic fungi from 1990-2014. This includes compounds with antimicrobial, anti-inflammatory, anti-proliferative and cytotoxic activity towards human cancer cell lines, and activity against either plant pathogens or plant insect pests. Compounds that were originally reported without associated activity were included if other studies ascribed activity to these compounds. Compounds were not included if they were exclusively phytotoxic or if they were isolated from active extracts but were not determined to be the active component of that extract.

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Figures

Figure 1
Figure 1
Structures of compounds 1–3.
Figure 2
Figure 2
Structure of compound 4.
Figure 3
Figure 3
Structure of compounds 5–6.
Figure 4
Figure 4
Structure of compound 7.
Figure 5
Figure 5
Structures of compounds 8–13.
Figure 6
Figure 6
Structures of compounds 14–17.
Figure 7
Figure 7
Structure of compound 18.
Figure 8
Figure 8
Structures of compounds 19–21.
Figure 9
Figure 9
Structures of compounds 22–26.
Figure 10
Figure 10
Structure of compound 27.
Figure 11
Figure 11
Structures of compounds 28–30.
Figure 12
Figure 12
Structures of compounds 31 and 32.
Figure 13
Figure 13
Structures of compounds 33–35.
Figure 14
Figure 14
Structures of compounds 36–38.
Figure 15
Figure 15
Structure of compound 39.
Figure 16
Figure 16
Structures of compounds 40 and 41.
Figure 17
Figure 17
Structures of compounds 42–43.
Figure 18
Figure 18
Structures of compounds 44–47.
Figure 19
Figure 19
Structures of compound 48 and 49.
Figure 20
Figure 20
Structures of compounds 50–53.
Figure 21
Figure 21
Structures of compounds 54 and 55
Figure 22
Figure 22
Structure of compound 56.
Figure 23
Figure 23
Structure of compound 57.
Figure 24
Figure 24
Structures of compounds 58–60.
Figure 25
Figure 25
Structures of compounds 61–63.
Figure 26
Figure 26
Structures of 64–65.
See this image and copyright information in PMC

References

    1. Stierle A, Strobel G, Stierle D. Taxol and taxane production by Taxomyces andreanae an endophytic fungus of Pacific yew. Science. 1993;260:214–216. - PubMed
    1. Kimura M, Anzai H, Yamaguchi I. Microbial toxins in plant-pathogen interactions: Biosynthesis, resistance mechanisms, and significance. Journal of General and Applied Microbiology. 2001;47:149–160. - PubMed

    1. http://masters.agron.iastate.edu/classes/514/lesson06/6.2.1.html

    1. Hirsch GU, Braun U. Communities of parasitic microfungi. In: Winterhoff W, editor. Handbook of Vegetation Science: Fungi in Vegetation Science. Vol. 19. Kluwer Academic; Dordrecht: 1992. pp. 225–250.
    1. Grove JF, MacMillan J, Mulholland TPC, Rogers MAT. 762. Griseofulvin. Part IV. Structure. Journal of the Chemical Society. 1952:3977–3987. Resumed.

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