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. 2015 Nov-Dec;37(6):420-2.
doi: 10.1016/j.bjhh.2015.08.001. Epub 2015 Sep 4.

Van den Berghe's 5q- syndrome and myelodysplastic syndrome with isolated del(5q)

Diego Silva Lima  1 , Paola Torres Costa  2 , Daniel Mazza Matos  3
Affiliations

Van den Berghe's 5q- syndrome and myelodysplastic syndrome with isolated del(5q)

Diego Silva Lima et al. Rev Bras Hematol Hemoter. 2015 Nov-Dec.
No abstract available

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Figures

Figure 1
Figure 1
(a) Megakaryocyte with a non-lobulated nucleus. (b) A ‘dumbbell-type’ megakaryocyte. (c) Karyotype showing a large terminal deletion of chromosome 5 – 46,XX,del(5)(q22).
See this image and copyright information in PMC

References

    1. Van den Berghe H., Cassiman J.J., David G., Fryns J.P., Michaux J.L., Sokal G. Distinct haematological disorder with deletion of long arm of no 5 chromosome. Nature. 1974;251:437–438. - PubMed
    1. Corey S.J., Minden M.D., Barber D.L., Kantarjian H., Wang J.C., Schimmer A.D. Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Cancer. 2007;7(2):118–129. - PubMed
    1. Komrokji R.S., Padron E., Ebert B.L. List AF deletions 5q MDS: molecular and therapeutic implications. Best Pract Res Clin Haematol. 2013;26(4):365–375. - PubMed
    1. Ebert B.L. Molecular dissection of the 5q deletion in myelodysplastic syndrome. Semin Oncol. 2011;38(5):621–626. - PMC - PubMed
    1. Gaballa M.R., Besa E.C. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide. Ann Hematol. 2014;93(5):723–733. - PubMed

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