So Far, PCSK9 Inhibitors Work for All Heterozygous FH Patients

Affiliations

¹ From the Division of Pediatric Genetics & Metabolism (M.C.M.), and Division of Nutrition & Metabolic Diseases (Z.A.), Center for Human Nutrition, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.
² From the Division of Pediatric Genetics & Metabolism (M.C.M.), and Division of Nutrition & Metabolic Diseases (Z.A.), Center for Human Nutrition, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX. Zahid.ahmad@utsouthwestern.edu.

Editorial

Markey C McNutt et al. Circ Cardiovasc Genet. 2015 Dec.

. 2015 Dec;8(6):749-51.

doi: 10.1161/CIRCGENETICS.115.001256.

¹ From the Division of Pediatric Genetics & Metabolism (M.C.M.), and Division of Nutrition & Metabolic Diseases (Z.A.), Center for Human Nutrition, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.
² From the Division of Pediatric Genetics & Metabolism (M.C.M.), and Division of Nutrition & Metabolic Diseases (Z.A.), Center for Human Nutrition, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX. Zahid.ahmad@utsouthwestern.edu.

No abstract available

Keywords: Editorials; LDLR; PCSK9; cardiovascular disease; hypercholesterolemia; lipoprotein; pharmacology; treatment.

Comment on

Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody.
Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabès JP, Carrié A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri MA, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B, Katsuda S, Kishimoto I, Lambert G, Makino H, Miyamoto Y, Pichelin M, Yagi K, Yamagishi M, Zair Y, Mellis S, Yancopoulos GD, Stahl N, Mendoza J, Du Y, Hamon S, Krempf M, Swergold GD. Hopkins PN, et al. Circ Cardiovasc Genet. 2015 Dec;8(6):823-31. doi: 10.1161/CIRCGENETICS.115.001129. Epub 2015 Sep 15. Circ Cardiovasc Genet. 2015. PMID: 26374825 Free PMC article. Clinical Trial.