Primary Squamous Cell Carcinoma of Urinary Bladder - A Rare Histological Variant

Abstract

Primary squamous cell carcinoma of urinary bladder is a rare histological variant of epithelial bladder tumours. Histopathological types are associated with significant disease outcome, so it is essential to find, on microscopy the exact type of urothelial carcinoma. Herewith, we present a 70-year-old male having 3 months history of difficulty in micturition, reduced frequency of urine and associated pain. On Contrast Enhanced CT scan abdomen pelvis, showed irregular large urinary bladder mass with hydroureter and hydronephrosis. Internal iliac group of lymphnodes was enlarged. On histopathology diagnosed as pure squamous cell carcinoma of urinary bladder grade II with muscle invasion. We are presenting this case for its clinical, radiological and histopathological findings.

Keywords: Haematuria; Histopathology; Tumours of urinary bladder.

[Table/Fig-1a]:

Showing gross image of urinary bladder tumour

[Table/Fig-1b]:

Photomicrograph showing tumour composed of neoplastic squamous cells arranged in epithelial fronds and large sheets. [H&E stain, 100X]

[Table/Fig-2]:

Photomicrograph showing neoplastic squamous cell having moderately pleomorphic hyperchromatic to vesicular nuclei, occasional nucleoli and mild to moderate amount of eosinophilic cytoplasm. [H&E stain, 400X]

[Table/Fig-3]:

Photomicrograph showing keratin pearls along with individual cell keratinisation. [H&E stain, 100X]