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. 2016 Jan 26;55(5):1849-53.
doi: 10.1002/anie.201509341. Epub 2015 Dec 16.

An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles

Vasudev R Bhonde  1 , Brian T O'Neill  2 , Stephen L Buchwald  3
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An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles

Vasudev R Bhonde et al. Angew Chem Int Ed Engl. .

Abstract

The development of a palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with octanoic acid/sodium octanoate as a simple and effective surfactant system provided an improved catalyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated in situ.

Keywords: alkyl zinc reagents; cross-coupling; micelles; palladium precatalysts; surfactants.

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