Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination"

Affiliations

¹ Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. p.young@uq.edu.au katryn.stacey@uq.edu.au.
² Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

Comment

Katryn J Stacey et al. Sci Transl Med. 2015.

. 2015 Dec 16;7(318):318lr4.

doi: 10.1126/scitranslmed.aad8657.

¹ Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. p.young@uq.edu.au katryn.stacey@uq.edu.au.
² Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

Abstract

Multiple risk factors may cause progression to severe dengue.

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity.
Modhiran N, Watterson D, Muller DA, Panetta AK, Sester DP, Liu L, Hume DA, Stacey KJ, Young PR. Modhiran N, et al. Sci Transl Med. 2015 Sep 9;7(304):304ra142. doi: 10.1126/scitranslmed.aaa3863. Sci Transl Med. 2015. PMID: 26355031
Comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination".
Halstead SB. Halstead SB. Sci Transl Med. 2015 Dec 16;7(318):318le4. doi: 10.1126/scitranslmed.aad4863. Sci Transl Med. 2015. PMID: 26676605