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Clinical Trial
. 1989 Sep 1;64(5):1007-10.
doi: 10.1002/1097-0142(19890901)64:5<1007::aid-cncr2820640506>3.0.co;2-u.

The effect of tamoxifen and estrogen receptor status on survival in gastric carcinoma

J D Harrison  1 , D L Morris, I O Ellis, J A Jones, I Jackson
Affiliations
Clinical Trial

The effect of tamoxifen and estrogen receptor status on survival in gastric carcinoma

J D Harrison et al. Cancer. .

Abstract

One hundred patients were entered in a randomized, controlled study of adjuvant tamoxifen therapy in gastric carcinoma. Estrogen receptor status was established by an immunohistologic method (ERD5) and 55.8% of the tumors were positive. Tamoxifen had no overall effect on survival, but there was a significant decrease in the survival time of the patients with ERD5-positive tumors. Estrogen receptor status (by the ERD5 method) is an independent prognostic factor in gastric cancer. Tamoxifen therapy does not prolong survival, and new therapeutic strategies require investigation.

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