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. 2015 Dec 14;28(6):679-680.
doi: 10.1016/j.ccell.2015.12.001.

Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay

Oren J Becher  1 , Eric C Holland  2
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Glioma Stem-like Cells Keep Their H3.3 Variant Levels at Bay

Oren J Becher et al. Cancer Cell. .
Free article

Abstract

Pediatric glioblastomas (GBMs) commonly harbor mutations in histone variant H3.3, while adult GBMs do not. In this issue of Cancer Cell, Gallo and colleagues demonstrate that adult GBM stem-like cells repress H3.3 expression to maintain self-renewal properties.

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