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. 1989 Sep;57(9):2842-6.
doi: 10.1128/iai.57.9.2842-2846.1989.

Salmonella typhimurium virulence in a burned-mouse model

M Carsiotis  1 , B A Stocker, I A Holder
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Salmonella typhimurium virulence in a burned-mouse model

M Carsiotis et al. Infect Immun. 1989 Sep.

Abstract

Various features of salmonellosis were examined in a burned-mouse model. In this model, which uses an outbred mouse strain, a challenge dose of ca. 100 CFU with any of several strains of Salmonella typhimurium caused a fatal infection. A variety of mutated strains attenuated for virulence in Salmonella-susceptible parenterally infected mice were also attenuated in the burned-mouse model. When administered as live vaccines injected intraperitoneally the same attenuated strains provided between slight and complete protection against subsequent lethal challenge subcutaneously at the site of a burn. The correspondence of results obtained in the burned-mouse model with those seen in other mouse models coupled with the unique advantages of the burned-mouse model argue for the usefulness of the model in studies of salmonellosis and in testing of strains constructed for use as live vaccines.

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References

    1. Adv Genet. 1971;16:1-34 - PubMed
    1. J Infect Dis. 1975 Jun;131(6):688-91 - PubMed
    1. Infect Immun. 1988 Feb;56(2):419-23 - PubMed
    1. Curr Top Microbiol Immunol. 1986;124:37-48 - PubMed
    1. Bacteriol Rev. 1974 Dec;38(4):371-402 - PubMed

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