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Meta-Analysis
. 2016 Jan 26;7(4):4483-9.
doi: 10.18632/oncotarget.6605.

Diabetes mellitus and the risk of glioma: a meta-analysis

Luqian Zhao  1 , Zhiping Zheng  1 , Ping Huang  1
Affiliations
Meta-Analysis

Diabetes mellitus and the risk of glioma: a meta-analysis

Luqian Zhao et al. Oncotarget. .

Abstract

Some studies reported a statistically significant inverse association between diabetes mellitus (DM) and risk of gliomas. However, the result is still controversial. We thus did a meta-analysis and summarized the evidence on the incidence of gliomas that has been studied in its association with DM. Seven case-control studies and 4 cohort studies were selected in this meta-analysis (n = 5898251). DM was significantly associated with decreased risk of gliomas (OR = 0.79; 95% CI 0.67 - 0.93; P = 0.004; I2 = 59%). In the subgroup analysis of race, Caucasians of DM showed decreased risk of gliomas (OR = 0.81; 95% CI 0.69 - 0.94; P = 0.007). In the subgroup analysis of design, a statistically significant protective effect of DM on gliomas was observed in case-control studies (OR = 0.68; 95 % CI, 0.53-0.87; P = 0.002), while no such effect was observed in cohort studies (OR = 0.97; 95 % CI, 0.83-1.13; P = 0.70). In a further stratified analysis by gender, a significant association was found among males with DM (OR = 0.83; 95 % CI, 0.70-0.99; P = 0.04). No significant association was found between females with DM and gliomas (OR = 0.97; 95 % CI, 0.78-1.21; P = 0.81). In summary, this meta-analysis of current evidence suggests that DM is significantly associated with decreased gliomas risk in Caucasian and males.

Keywords: association; diabetes; glioma; meta-analysis.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. The selection of included studies
Figure 2
Figure 2. Meta-analysis of the association between DM and risk of gliomas
Figure 3
Figure 3. Sensitivity analysis of the association between DM and risk of gliomas
Figure 4
Figure 4. Funnel plot of the association between DM and risk of gliomas
See this image and copyright information in PMC

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