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Review
. 2016;11(1):137-51.
doi: 10.2217/fmb.15.128. Epub 2015 Dec 18.

Hfq: a multifaceted RNA chaperone involved in virulence

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Review

Hfq: a multifaceted RNA chaperone involved in virulence

Joana R Feliciano et al. Future Microbiol. 2016.

Abstract

Hfq has emerged in recent years as a master regulator of gene expression in bacteria, mainly due to its ability to mediate the interaction of small noncoding RNAs with their mRNA targets, including those related to virulence in Gram-negative bacteria. In this work, we review current knowledge on the involvement of Hfq in the regulation of virulence traits related to secretion systems, alternative sigma factors, outer membrane proteins, polysaccharides and iron metabolism. Recent data from transcriptomics and proteomics studies performed for major pathogens are included. We also summarize and correlate current knowledge on how Hfq protein impacts pathogenicity of bacterial pathogens.

Keywords: Hfq protein; bacterial pathogenesis; post-transcriptional regulation; proteomics; sRNAs; transcriptomics.

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