Drug the Bug!

Annika Lindskog Jonsson¹, Fredrik Bäckhed²

Affiliations

¹ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden.
² The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: fredrik.backhed@wlab.gu.se.

PMID: 26687345
DOI: 10.1016/j.cell.2015.12.005

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Drug the Bug!

Annika Lindskog Jonsson et al. Cell. 2015.

Free article

. 2015 Dec 17;163(7):1565-6.

doi: 10.1016/j.cell.2015.12.005.

Authors

Annika Lindskog Jonsson¹, Fredrik Bäckhed²

Affiliations

¹ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden.
² The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: fredrik.backhed@wlab.gu.se.

PMID: 26687345
DOI: 10.1016/j.cell.2015.12.005

Abstract

Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo.

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Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.
Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL. Wang Z, et al. Cell. 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055. Cell. 2015. PMID: 26687352 Free PMC article.

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Drug the Bug!

Affiliations

Drug the Bug!

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

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LinkOut - more resources

Full Text Sources

Medical