Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

Francois E Mercier¹, David T Scadden²

Affiliations

¹ Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA.
² Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: david_scadden@harvard.edu.

PMID: 26687347
DOI: 10.1016/j.cell.2015.12.013

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Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

Francois E Mercier et al. Cell. 2015.

Free article

. 2015 Dec 17;163(7):1568-70.

doi: 10.1016/j.cell.2015.12.013.

Authors

Francois E Mercier¹, David T Scadden²

Affiliations

¹ Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA.
² Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: david_scadden@harvard.edu.

PMID: 26687347
DOI: 10.1016/j.cell.2015.12.013

Abstract

The multiple cell types comprising blood have been thought to emerge from progenitors with progressively narrower lineage options. New data suggest that lineage fate may be determined earlier than thought and that myeloid progenitor populations are aggregates of individual lineage-restricted cells.

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Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.
Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I. Paul F, et al. Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013. Epub 2015 Nov 25. Cell. 2015. PMID: 26627738
The Branching Point in Erythro-Myeloid Differentiation.
Perié L, Duffy KR, Kok L, de Boer RJ, Schumacher TN. Perié L, et al. Cell. 2015 Dec 17;163(7):1655-62. doi: 10.1016/j.cell.2015.11.059. Cell. 2015. PMID: 26687356

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Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

Affiliations

Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

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