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Comment
. 2015 Dec 17;163(7):1572-4.
doi: 10.1016/j.cell.2015.12.004.

How Low Cholesterol Is Good for Anti-viral Immunity

Luke A J O'Neill  1
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Free article
Comment

How Low Cholesterol Is Good for Anti-viral Immunity

Luke A J O'Neill. Cell. .
Free article

Abstract

York et al. identify a role for decreased cholesterol biosynthesis in virally infected cells as a critical event in the induction of the anti-viral response. The mechanism involves enhanced signaling by STING in the ER membrane in response to the second messenger cGAMP, promoting increased transcription of type I interferons. The authors suggest that a "lipid code" is being sensed by STING to allow it to signal.

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  • Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
    York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. York AG, et al. Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10. Cell. 2015. PMID: 26686653 Free PMC article.

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