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Review
. 2015:2015:741972.
doi: 10.1155/2015/741972. Epub 2015 Nov 24.

Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis

Hong Weng  1 , Chao Zhang  2 , Yuan-Yuan Hu  3 , Rui-Xia Yuan  2 , Hong-Xia Zuo  2 , Jin-Zhu Yan  1 , Yu-Ming Niu  4
Affiliations
Review

Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis

Hong Weng et al. Dis Markers. 2015.

Abstract

Background: Certain studies have previously explored the association between the estrogen receptor-α (ER-α) gene polymorphisms and periodontitis susceptibility, although the current results are controversial. The present study, using meta-analysis, aimed to investigate the nature of the genetic susceptibility of the ER-α for developing periodontitis.

Methods: A comprehensive literature search of PubMed, Embase, CNKI, and Wanfang databases was conducted up to January 8, 2015. Statistical manipulation was performed using Stata version 13.0 software. Odds ratios (ORs) and corresponding 95% confident intervals (CIs) were calculated to estimate the association in five genetic models.

Results: A total of 17 eligible case-control studies from seven identified publications consisting of nine studies for the XbaI polymorphism and eight studies for the PvuII polymorphism were included in the meta-analysis. We found elevated risk of periodontitis in XbaI XX genotype carriers. Moreover, subgroup analyses demonstrated increased risk for chronic periodontitis of XbaI XX genotype carriers, specifically in the Chinese Han female population. No significant association was observed between PvuII polymorphism and periodontitis.

Conclusion: Current evidence indicated that the homozygote (XX) genotype of ER-α gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.

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Figures

Figure 1
Figure 1
Flowchart for study section of this meta-analysis.
Figure 2
Figure 2
Forest plot for estrogen receptor-α gene XbaI polymorphism associated with risk of chronic and aggressive periodontitis in X versus x allele comparison in all study subjects.
Figure 3
Figure 3
Funnel plot for publication bias for estrogen receptor-α gene XbaI polymorphism based on X versus x allele model.
See this image and copyright information in PMC

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