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. 2016 Jan;22(1):92-5.
doi: 10.3201/eid2201.151323.

Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia

Paul F Horwood, Alessio Andronico, Arnaud Tarantola, Henrik Salje, Veasna Duong, Channa Mey, Sovann Ly, Philippe Dussart, Simon Cauchemez, Philippe Buchy

Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia

Paul F Horwood et al. Emerg Infect Dis. 2016 Jan.

Abstract

Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

Keywords: Cambodia; EV71; children; encephalitis; enterovirus; seroprevalence; viruses.

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Figures

Figure 1
Figure 1
Age-associated seroprevalence of enterovirus 71 (EV71) infection in Cambodia, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age, 2000–2011. Error bars indicate 95% CIs. Serum samples were collected from routine national dengue surveillance in Cambodia.
Figure 2
Figure 2
Annual probability of enterovirus 71 infection (EV71) in Cambodia during 1994–2011, estimated by detection of EV71 seroneutralizing antibodies in inpatient children 2–15 years of age. Serum samples were collected from routine national dengue surveillance in Cambodia.
See this image and copyright information in PMC

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