Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Dec;2(1):16.
doi: 10.1186/s40348-015-0027-1. Epub 2015 Dec 21.

Expression and function of histamine and its receptors in atopic dermatitis

M Albrecht  1 , A M Dittrich  2
Affiliations

Expression and function of histamine and its receptors in atopic dermatitis

M Albrecht et al. Mol Cell Pediatr. 2015 Dec.

Abstract

Background: Atopic dermatitis constitutes a most burdensome chronic inflammatory skin disease. Standard treatment is cumbersome and often targets its main symptom, pruritus, only insufficiently.

Findings: Recent advances in our understanding of the role of histamine and its four receptors suggest new approaches which target the histamine receptors alone or as combination therapies to more efficiently combat pruritus and inflammation in atopic dermatitis.

Conclusions: With this review, we provide an overview on histamine and the expression of its four receptors on skin resident and nonresident cells. Furthermore, we summarize recent studies which suggest anti-histamine therapy to efficiently combat pruritus and inflammation in atopic dermatitis and discuss possible approaches to incorporate these findings into more effective treatment strategies for atopic dermatitis in childhood.

Keywords: Atopic dermatitis; Histamine; Histamine receptors; Immunology; Treatment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arkwright PD, Stafford JC, Sharma V. Atopic dermatitis in children. J Allergy Clin Immunol Pract. 2014;2:388–95. doi: 10.1016/j.jaip.2014.01.016. - DOI - PubMed
    1. Novak N, Bieber T, Leung DY. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003;112:S128–39. doi: 10.1016/j.jaci.2003.09.032. - DOI - PubMed
    1. Saeki H, Tamaki K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J Dermatol Sci. 2006;43:75–84. doi: 10.1016/j.jdermsci.2006.06.002. - DOI - PubMed
    1. Imaizumi A, Kawakami T, Murakami F, Soma Y, Mizoguchi M. Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels. J Dermatol Sci. 2003;33:23–9. doi: 10.1016/S0923-1811(03)00132-4. - DOI - PubMed
    1. Greaves MW. Antihistamines in dermatology. Skin Pharmacol Physiol. 2005;18:220–9. doi: 10.1159/000086667. - DOI - PubMed