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Review
. 2015 Dec 4;7(12):10129-44.
doi: 10.3390/nu7125524.

Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?

Deepika Garg  1 , Zaher Merhi  2
Affiliations
Review

Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?

Deepika Garg et al. Nutrients. .

Abstract

PCOS is the most common cause of anovulation in reproductive-aged women with 70% experiencing ovulatory problems. Advanced glycation end products are highly reactive molecules that are formed by non-enzymatic reactions of sugars with proteins, nucleic acids and lipids. AGEs are also present in a variety of diet where substantial increase in AGEs can result due to thermal processing and modifications of food. Elevation in bodily AGEs, produced endogenously or absorbed exogenously from high-AGE diets, is further exaggerated in women with PCOS and is associated with ovulatory dysfunction. Additionally, increased expression of AGEs as pro-inflammatory receptors in the ovarian tissue has been observed in women with PCOS. In this review, we summarize the role of dietary AGEs as mediators of metabolic and reproductive alterations in PCOS. Once a mechanistic understanding of the relationship between AGEs and anovulation is established, there is a promise that such knowledge will contribute to the subsequent development of targeted pharmacological therapies that will treat anovulation and improve ovarian health in women with PCOS.

Keywords: advanced glycation end products; anovulation; polycystic ovary syndrome (PCOS); receptor for advanced glycation endproducts (RAGE); soluble receptor for advanced glycation end products (sRAGE).

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Figures

Figure 1
Figure 1
Possible Roles of dietary AGEs in PCOS.
Figure 2
Figure 2
Possible involvement of AGEs in ovulatory dysfunction in PCOS.
See this image and copyright information in PMC

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