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. 2015 Dec;5(1):53.
doi: 10.1186/s13613-015-0097-1. Epub 2015 Dec 21.

Clinical characteristics and outcome of very elderly patients ≥90 years in intensive care: a retrospective observational study

Sophie Becker  1 , Jakob Müller  2   3 , Geraldine de Heer  4 , Stephan Braune  5 , Valentin Fuhrmann  6 , Stefan Kluge  7
Affiliations

Clinical characteristics and outcome of very elderly patients ≥90 years in intensive care: a retrospective observational study

Sophie Becker et al. Ann Intensive Care. 2015 Dec.

Abstract

Background: Since the overall prognosis of very elderly patients is generally limited, admissions to intensive care in these patients are often restricted. Therefore, only very few information is available on the prognosis of nonagenarians after intensive care treatment. The aim of this study was to analyze the clinical characteristics and outcomes of very elderly patients (≥90 years) admitted to an intensive care unit (ICU).

Methods: Monocentric, retrospective observational study of all patients aged ≥90 years admitted to the Department of Intensive Care Medicine with a total capacity of 132 ICU beds at the University Medical Center Hamburg in Germany between January 2008 and June 2013. A multivariate Cox regression analysis was used to identify risk factors for 28-day outcome.

Results: A total of 372 patients ≥90 years of age were admitted to one of the departments ICUs. The majority of patients (66.7 %) were admitted as an emergency admission, of which half underwent unscheduled surgery. 39.8 % of patients required support by mechanical ventilation and vasoactive drugs, and 1.9 % of patients received renal replacement. ICU and hospital mortality rates were 18.3 and 30.9 %, respectively. Overall survival at 1 year after hospital discharge was 34.9 %. Multivariate Cox regression analysis revealed creatinine, bilirubin, age, and necessity of catecholamines as independent risk factors and scheduled surgery as protective factor for 28-day outcome.

Conclusion: Nearly 70 % of patients aged ≥90 years were discharged alive from hospital following treatment at the ICU, and more than half of them were still alive 1 year after their discharge. The results suggest that 1-year survival prognosis of very old ICU patients is not as poor as often perceived and that age per se should not be an exclusion criterion for ICU admission.

Trial registration: WF-0561/13.

Keywords: Intensive care; Long- term outcome; Over 90 years old; Prognosis.

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Figures

Fig. 1
Fig. 1
Trends in admission and mortality. Absolute number, mortality, and proportion of nonagenarians in intensive care over time
Fig. 2
Fig. 2
Survival from Intensive care unit (ICU) admission. Kaplan–Meier survival curve: patients after medical admission (blue), planned surgery (green) and unplanned surgery (gray). Groups were compared via Log-rank test (p < 0.01)
See this image and copyright information in PMC

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