Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

Kenneth I Berns^{1

2

3}, Barry J Byrne^{1

2

3

4}, Terence R Flotte^{5

6}, Guangping Gao^{6

7}, William W Hauswirth^{2

8}, Roland W Herzog^{1

2

3

4}, Nicholas Muzyczka^{1

2

3}, Thierry VandenDriessche⁹, Xiao Xiao^{10

11}, Sergei Zolotukhin^{1

2

3

4}, Arun Srivastava^{1

2

3

4}

Affiliations

¹ 1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
² 2 Genetics Institute, University of Florida College of Medicine , Gainesville, Florida.
³ 3 Department of Molecular Genetics and Microbiology, University of Florida College of Medicine , Gainesville, Florida.
⁴ 4 Department of Pediatrics, University of Florida College of Medicine , Gainesville, Florida.
⁵ 5 Office of the Dean, University of Massachusetts Medical School , Worcester, Massachusetts.
⁶ 6 Horae Gene Therapy Center, University of Massachusetts Medical School , Worcester, Massachusetts.
⁷ 7 Microbiology and Physiological Systems, University of Massachusetts Medical School , Worcester, Massachusetts.
⁸ 8 Department of Ophthalmology, University of Florida College of Medicine , Gainesville, Florida.
⁹ 9 Department of Gene Therapy and Regenerative Medicine, Free University of Brussels , Brussels, Belgium .
¹⁰ 10 Department of Molecular Pharmaceutics, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
¹¹ 11 Gene Therapy Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.

PMID: 26690810
PMCID: PMC4809064
DOI: 10.1089/hum.2015.29014.kib

Comment

Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

Kenneth I Berns et al. Hum Gene Ther. 2015 Dec.

. 2015 Dec;26(12):779-81.

doi: 10.1089/hum.2015.29014.kib.

Authors

Affiliations

¹ 1 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
² 2 Genetics Institute, University of Florida College of Medicine , Gainesville, Florida.
³ 3 Department of Molecular Genetics and Microbiology, University of Florida College of Medicine , Gainesville, Florida.
⁴ 4 Department of Pediatrics, University of Florida College of Medicine , Gainesville, Florida.
⁵ 5 Office of the Dean, University of Massachusetts Medical School , Worcester, Massachusetts.
⁶ 6 Horae Gene Therapy Center, University of Massachusetts Medical School , Worcester, Massachusetts.
⁷ 7 Microbiology and Physiological Systems, University of Massachusetts Medical School , Worcester, Massachusetts.
⁸ 8 Department of Ophthalmology, University of Florida College of Medicine , Gainesville, Florida.
⁹ 9 Department of Gene Therapy and Regenerative Medicine, Free University of Brussels , Brussels, Belgium .
¹⁰ 10 Department of Molecular Pharmaceutics, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
¹¹ 11 Gene Therapy Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.

PMID: 26690810
PMCID: PMC4809064
DOI: 10.1089/hum.2015.29014.kib

No abstract available

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Comment in

AAV2 and Hepatocellular Carcinoma.
Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouzé E, Pilati C, Verret B, Blanc JF, Balabaud C, Calderaro J, Laurent A, Letexier M, Bioulac-Sage P, Calvo F, Zucman-Rossi J. Nault JC, et al. Hum Gene Ther. 2016 Mar;27(3):211-3. doi: 10.1089/hum.2016.002. Hum Gene Ther. 2016. PMID: 26935016 No abstract available.

Comment on

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouzé E, Pilati C, Verret B, Blanc JF, Balabaud C, Calderaro J, Laurent A, Letexier M, Bioulac-Sage P, Calvo F, Zucman-Rossi J. Nault JC, et al. Nat Genet. 2015 Oct;47(10):1187-93. doi: 10.1038/ng.3389. Epub 2015 Aug 24. Nat Genet. 2015. PMID: 26301494

References

1. Nault J-C, Datta S, Imbeaud S, et al. . Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet 2015;47:1187–1193 - PubMed
1. Blacklow NR, Hoggan MD, Sereno MS, et al. . A seroepidemiologic study of adenovirus-associated virus infection in infants and children. Am J Epidemiol 1971;94:359–366 - PubMed
1. Mayor HD, Houlditch GS, and Mumford DM. Influence of adeno-associated satellite virus on adenovirus-induced tumours in hamsters. Nat New Biol 1973;241:44–46 - PubMed
1. Cukor G, Blacklow NR, Kibrick S, et al. . Effect of adeno-associated virus on cancer expression by herpesvirus-transformed hamster cells. J Natl Cancer Inst 1975;55:957–959 - PubMed
1. Ostrove JM, Duckworth DH, and Berns KI. Inhibition of adenovirus-transformed cell oncogenicity by adeno-associated virus. Virology 1981;113:521–533 - PubMed

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Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

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Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

Authors

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Comment in

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