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. 2015 Apr 26:2:e779.
doi: 10.14800/Macrophage.779.

Macrophage cell death upon intracellular bacterial infection

Xin-He Lai  1 , Yunsheng Xu  2 , Xiao-Ming Chen  3 , Yi Ren  4
Affiliations

Macrophage cell death upon intracellular bacterial infection

Xin-He Lai et al. Macrophage (Houst). .

Abstract

Macrophage-pathogen interaction is a complex process and the outcome of this tag-of-war for both sides is to live or die. Without attempting to be comprehensive, this review will discuss the complexity and significance of the interaction outcomes between macrophages and some facultative intracellular bacterial pathogens as exemplified by Francisella, Salmonella, Shigella and Yersinia. Upon bacterial infection, macrophages can die by a variety of ways, such as apoptosis, autophagic cell death, necrosis, necroptosis, oncosis, pyronecrosis, pyroptosis etc, which is the focus of this review.

Keywords: apoptosis; autophagic cell death; bacterial pathogen; macrophage polarization; necroptosis; necrosis; oncosis; pyronecrosis; pyroptosis.

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Conflict of interest statement

Conflict of interest statement

The authors declare that they have no conflict of interest.

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References

    1. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012;19:107–120. - PMC - PubMed
    1. Zychlinsky A, Prevost MC, Sansonetti PJ. Shigella flexneri induces apoptosis in infected macrophages. Nature. 1992;358:167–169. - PubMed
    1. Chen LM, Kaniga K, Galán JE. Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol. 1996;21:1101–1115. - PubMed
    1. Monack DM, Raupach B, Hromockyj AE, Falkow S. Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc Natl Acad Sci U S A. 1996;93:9833–9838. - PMC - PubMed
    1. Mills SD, Boland A, Sory MP, van der Smissen P, Kerbourch C, Finlay BB, et al. Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein. Proc Natl Acad Sci U S A. 1997;94:12638–12643. - PMC - PubMed

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