Impact of treatment strategies for open angle glaucoma on intraocular pressure: the RiGOR study

Abstract

Aims: The RiGOR study's primary outcome measure was a 15% reduction in intraocular pressure (IOP) for patients with open-angle glaucoma at 1 year.

Methods: Patients received treatment according to the ophthalmologist's usual practice.

Results: A higher proportion of patients in the incisional and other surgery group achieved a 15% reduction in IOP than in the laser surgery or additional medication groups (82, 57, and 57% respectively). In multivariate regression analyses, incisional surgery patients were 2.7-times as likely as patients treated with additional medication to achieve a 15% reduction in IOP (odds ratio: 2.67; 95% CI: 2.01-3.57).

Conclusion: Incisional and other surgical procedures are effective treatments. There were no differences in treatment response by race or ethnicity.

Keywords: comparative effectiveness; glaucoma medication; glaucoma surgery; intraocular pressure; open-angle glaucoma; registry.