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. 2016 Aug;45(7):974-9.
doi: 10.1097/MPA.0000000000000580.

Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma

Ashley H Davis-Yadley  1 , Andrea M Abbott, Jose M Pimiento, Dung-Tsa Chen, Mokenge P Malafa
Affiliations

Increased Expression of the Glucose Transporter Type 1 Gene Is Associated With Worse Overall Survival in Resected Pancreatic Adenocarcinoma

Ashley H Davis-Yadley et al. Pancreas. 2016 Aug.

Abstract

Objectives: There is currently no reliable method to predict the risk of relapse after curative resection of early-stage pancreatic adenocarcinoma. Increased glucose metabolism observed on F-fluorodeoxyglucose positron emission tomography (PET) by malignant cells, the Warburg effect, is a well-known characteristic of the malignant phenotype. We investigated the role of glucose transporter type 1 (GLUT-1) gene expression, a glucose cell plasma membrane transporter, in early-stage pancreatic cancer.

Methods: Associations between GLUT-1 gene expression with PET maximum standardized uptake values and histologic grade were investigated in early-stage pancreatic adenocarcinoma patients. Multivariate analysis was conducted to determine predictors of prognosis. Cox proportional hazard model was used for survival analysis.

Results: Sixty-three patients had GLUT-1 gene analysis performed, and 50 patients had both GLUT-1 analysis and PET scan. Patients with high GLUT-1 gene expression had a decreased overall survival by univariate analysis using Cox proportional hazard model (hazard ratio, 2.82; P = 0.001) and remained significant on multivariate analysis (hazard ratio, 2.54; P = 0.03). There was no correlation of GLUT-1 gene expression with histologic grade or PET maximum standardized uptake values.

Conclusions: Increased GLUT-1 gene expression was associated with a decreased overall survival in pancreatic adenocarcinoma. This supports increased GLUT-1 gene expression as a potential prognostic marker in resected pancreatic adenocarcinoma.

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Conflict of interest statement

Conflicts of Interest

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1. Overall survival
Patients with high GLUT-1 gene expression had significantly decreased overall survival.
Figure 2
Figure 2. FDG PET SUVmax
There was no statistical correlation found between GLUT-1 gene expression and SUVmax.
Figure 3
Figure 3. Histologic Grade
There was no statistical correlation found between GLUT-1 gene expression and histologic grade.
See this image and copyright information in PMC

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