Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2015 Oct-Dec;22(4):462-6.
doi: 10.4103/0974-9233.167827.

A Clinical Study of Meibomian Gland Dysfunction in Patients with Diabetes

R P Shamsheer  1 , Cynthia Arunachalam  1
Affiliations
Comparative Study

A Clinical Study of Meibomian Gland Dysfunction in Patients with Diabetes

R P Shamsheer et al. Middle East Afr J Ophthalmol. 2015 Oct-Dec.

Abstract

Aims of the study: To study the frequency of meibomian gland dysfunction (MGD) in patients of diabetes mellitus with dry eye.

Materials and methods: A case-control cross sectional study.

Sampling: Purposive random sampling. Totally, 200 eyes of 100 patients of diabetes mellitus and an equal number of eyes of normal subjects as control, who were gender and age matched and all of whom were symptomatic for dry eye were assessed for MGD by noting the symptoms and determining the meibomian gland expression scale for volume and viscosity, and ocular surface staining with Lissamine green, and Fluorescein sodium. All the subjects were graded for the severity of MGD. The results were compared in both the groups to ascertain whether the frequency of MGD in diabetics is significantly more as compared to nondiabetics.

Statistical analysis: The data were analyzed by Chi-square test for significance. P < 0.05 was considered as statistically significant.

Results: There was a significant increase in the frequency of MGD in diabetics as compared to the nondiabetics.

Conclusion: Diabetes mellitus is associated with MGD.

Keywords: Dry Eye; Meibomian Gland Dysfunction; Meibomian Gland Expression Scale.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Oxford panel for grading of corneal and conjunctival staining
See this image and copyright information in PMC

References

    1. Research in dry eye: Report of the research subcommittee of the International Dry Eye Work Shop (2007) Ocul Surf. 2007;5:179–93. - PubMed
    1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53. - PubMed
    1. Gutgesell VJ, Stern GA, Hood CI. Histopathology of meibomian gland dysfunction. Am J Ophthalmol. 1982;94:383–7. - PubMed
    1. Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, et al. The international workshop on meibomian gland dysfunction: Executive summary. Invest Ophthalmol Vis Sci. 2011;52:1922–9. - PMC - PubMed
    1. Lambert DW. Physiology of the tear film. In: Smolin G, Thoft RA, editors. The Cornea. 3rd ed. Noida, India: Lippincott Williams and Wilkins; 2001. p. 439.

Publication types

MeSH terms