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. 2014 Oct-Dec;7(4):314-21.
doi: 10.4103/0974-8490.167893.

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

Nasrin Payghami  1 , Shahla Jamili  2 , Abdolhossein Rustaiyan  3 , Soodabeh Saeidnia  4 , Marjan Nikan  4 , Ahmad Reza Gohari  4
Affiliations

Alpha-amylase inhibitory activity and sterol composition of the marine algae, Sargassum glaucescens

Nasrin Payghami et al. Pharmacognosy Res. 2014 Oct-Dec.

Abstract

Background: Sargassum species (phaeophyceae) are economically important brown algae in southern parts of Iran. Sargassum is mainly harvested as a row material in alginate production industries and is a source of plant foods or plant bio-stimulants even a component of animal foods.

Objective: In this study, Sargassum glaucescens, collected from the seashore of Chabahar, was employed for phytochemical and biological evaluations.

Materials and methods: For that purpose, the dried algae was extracted by methanol and subjected to different chromatographic separation methods.

Results: Six sterols, fucosterol (1), 24(S)-hydroxy-24-vinylcholesterol (2), 24(R)-hydroxy-24-vinylcholesterol (3), stigmasterol (4), β-sitosterol (5) and cholesterol (6) were identified by spectroscopic methods including (1)H-NMR, (13)C-NMR and mass spectroscopy. In vitro alpha-amylase inhibitory test was performed on the methanolic extract and the results revealed a potent inhibition (IC50 = 8.9 ± 2.4 mg/mL) of the enzyme compared to acarbose as a positive control.

Conclusion: Various biological activities and distribution of sterols in Sargassum genus have been critically reviewed here. The results concluded that these algae are a good candidate for further anti-diabetic investigations in animals and human.

Keywords: Alpha-amylase inhibitor; Brown algae; Sargassum glaucescens; Sterol.

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Conflict of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1
Figure 1
Chemical structures of isolated sterols from Sargassum glaucescens
See this image and copyright information in PMC

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