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Review
. 2015 Oct 31;5(4):65-7.
doi: 10.5826/dpc.0504a16. eCollection 2015 Oct.

Diffuse normolipemic plane xanthoma associated with monoclonal gammopathy

Yoon K Cohen  1 , David J Elpern  2
Affiliations
Review

Diffuse normolipemic plane xanthoma associated with monoclonal gammopathy

Yoon K Cohen et al. Dermatol Pract Concept. .

Abstract

Diffuse normolipemic plane xanthoma (DNPX) was first described by Altman and Winkelmann in 1962. It is a rare and non-inherited form of xanthomatosis. Clinically, the dermatosis is characterized by the presence of symmetric yellowish-orange plaques that favor the neck, upper trunk, flexural folds and periorbital region. It has been recognized to be associated with hematological diseases, especially with multiple myeloma and monoclonal gammopathy. We present a patient with diffuse plane xanthoma, normal lipid level, and monoclonal gammopathy.

Keywords: diffuse normolipemic plane xanthoma; lymphoproliferative disorder; monoclonal gammopathy; multiple myeloma; paraproteinemia; plane xanthoma; xanthoma.

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Figures

Figure 1.
Figure 1.
Clinical view shows well-demarcated yellow patches and plaques covering large portions of the upper chest and shoulder with some islands of sparing. [Copyright: ©2015 Cohen et al.]
Figure 2.
Figure 2.
Well-demarcated yellow plaques on the upper back. [Copyright: ©2015 Cohen et al.]
Figure 3.
Figure 3.
Dermoscopic view shows a reticular pattern of yellow amorphous uniformed granules with overlying vascular structures. [Copyright: ©2015 Cohen et al.]
Figures. 4, 5, 6.
Figures. 4, 5, 6.
Histology views show scattered foamy histiocytes within the papillary dermis with a normal overlying epidermis, which were consistent with a plane xanthoma. [Copyright: ©2015 Cohen et al.]
Figures. 4, 5, 6.
Figures. 4, 5, 6.
Histology views show scattered foamy histiocytes within the papillary dermis with a normal overlying epidermis, which were consistent with a plane xanthoma. [Copyright: ©2015 Cohen et al.]
Figures. 4, 5, 6.
Figures. 4, 5, 6.
Histology views show scattered foamy histiocytes within the papillary dermis with a normal overlying epidermis, which were consistent with a plane xanthoma. [Copyright: ©2015 Cohen et al.]
See this image and copyright information in PMC

References

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    1. Hu CH, Winkelmann RK. Unusual normolipemic cutaneous xanthomatosis: a comparison of two cases illustrating the differential diagnosis. Acta Dermato-Venereol. 1977;57:421–9. - PubMed

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