How distinct Arp2/3 complex variants regulate actin filament assembly
- PMID: 26693915
- DOI: 10.1038/ncb3293
How distinct Arp2/3 complex variants regulate actin filament assembly
Abstract
The heptameric Arp2/3 complex generates branched actin filament networks that drive lamellipodium protrusion, vesicle trafficking and pathogen motility. Distinct variants of the Arp2/3 complex are now shown to have different roles in tuning actin assembly and disassembly, in concert with the prominent actin regulators cortactin and coronin.
Comment on
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Isoform diversity in the Arp2/3 complex determines actin filament dynamics.Nat Cell Biol. 2016 Jan;18(1):76-86. doi: 10.1038/ncb3286. Epub 2015 Dec 14. Nat Cell Biol. 2016. PMID: 26655834
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