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Comment
. 2016 Jan;18(1):3-5.
doi: 10.1038/ncb3294.

Heart disease modelling adds a Notch to its belt

Casey A Gifford  1 , Deepak Srivastava  1
Affiliations
Comment

Heart disease modelling adds a Notch to its belt

Casey A Gifford et al. Nat Cell Biol. 2016 Jan.

Abstract

The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.

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Comment on

  • Sequential Notch activation regulates ventricular chamber development.
    D'Amato G, Luxán G, del Monte-Nieto G, Martínez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jiménez-Borreguero LJ, de la Pompa JL. D'Amato G, et al. Nat Cell Biol. 2016 Jan;18(1):7-20. doi: 10.1038/ncb3280. Epub 2015 Dec 7. Nat Cell Biol. 2016. PMID: 26641715 Free PMC article.

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